Caveolins are a family of unique membrane proteins that are an essential component of building small invaginated membrane structures at the surface of cells known as caveolae. Caveolae serve as hubs for numerous signaling pathways, lipid homeostasis, intracellular transport, cell adhesion, and cell migration. We have used cryo-EM to determine the first high resolution structure of the Caveolin-1 oligomer. This structure in combination with cell biology and biophysical approaches has provided important insight into how Caveolin-1 interacts with membranes and may alter membrane architecture. A major focus of this presentation will be about the importance and power of embracing the capability of electron microscopy to visualize across many resolutions – moving from blobs to atoms and back to blobs.