Tuesday, 7th February The 48th Lorne Conference on Protein Structure and Function 2023

• Tunnels, Ferries and Bridges for lipid transport across the bacterial cell envelope - Gira Bhabha
• Structure and mechanistic basis of MFSD2A-mediated ω-3 fatty acid transport - Rosemary J Cater
• Molecular mechanism of phospholipid transport at the bacterial outer membrane interface - Shu-Sin Chng
• The wide wild world of human GABAA receptors - Radu Aricescu

• IDENTIFICATION OF NOVEL THERAPEUTIC TARGETS IN MUCINOUS OVARIAN CANCER - Jessica K Holien
• The cryo-EM structure of the human neurofibromin dimer reveals the molecular basis for neurofibromatosis type 1 - Chris J Lupton
• A Structural Model of the Human Plasminogen and Aspergillus fumigatus Enolase Complex: Insights for Antifungal Drug Discovery - Stephanie Nguyen
• Anti-Inflammatory Strategies Through Engineering of Natural Chemokine-Binding Proteins - Ram Bhusal
• Post-translational modification autoantigen-mediated T cell Immunity - Jia Jia Lim
• A general catalytic mechanism for RBR E3 ubiquitin ligases – rules and exceptions   - Thomas Cotton
• Moonlighting function for the acid phosphatase domain of Mycobacterium tuberculosis Ribonuclease HI - Stephanie S Dawes
• Blending Proteins: Democratising Access to Beautiful Molecular Landscapes - Brady A Johnston

• Cryo-EM analysis of the Caveolin-1 complex - Melanie Ohi
• Structure of the metastatic factor P-Rex1 reveals a two-layered autoinhibitory mechanism - Tyler Chang
• Breaking bond: The role of novel, functional disulfide bonds in G protein coupled receptors using integrative structural approaches - Sarah J Piper
• Cryo-EM structures of human arachidonate 12S-Lipoxygenase (12-LOX) bound to endogenous and exogenous inhibitors - Jesse I Mobbs
• Structural and Functional Characterization of Bacterial TIR Proteins - Sulin Li
• Structural basis of lipopolysaccharide biosynthesis - Filippo Mancia

The workshop will provide pizza for lunch.

• Structure and dynamics of class B1 peptide hormone G protein-coupled receptors   - Denise Wootten
• Structures of borate transporter AtBor1 of the SLC4 family reveal the mechanisms of auto-inhibition and transport - Yan Jiang
• Protein folding within the bacterial outer membrane - Matthew Doyle
• Architecture of erythrocyte ankyrin complexes - Oliver B Clarke

• The application of Aotearoa extremophile populations for the detection of volatile sulfur compounds in winemaking - Sarah Manners
• Crossing the barrier: Understanding the mechanism of entry of enveloped phages at molecular resolution - Somavally Dalvi
• Native nanodisc assembly by a novel alternating cationic polymer - Michelle Farrelly
• Characterization of the structure and dynamics of oral polymicrobial biofilms - Bindusmita Paul
• Structure based drug design against HOXA1 - Vinodini S Madugalle
• Optimizing the performance parameters of protein biosensors for novel diagnostic applications  - Cagla Ergun Ayva
• Protein-based biosensors for clinical-decision support for patients with heart failure - Roxane RM Mutschler
• Estimating divergence of sequence and structures using Markov time - Sanduni Rajapaksa
• A novel Tandem Affinity Purification (TAP) system for Cryptococcus neoformans - Chendi Yu
• Expanding diversity of Archaea expands the diversity of the Tubulin Superfamily of proteins - Stephanie J Nobs
• RaPID discovery and characterisation of RIPK3 RHIM-binding peptides - Jessica A Buchanan
• The structure and dynamics of lipid-free apolipoprotein A-I - Phoebe Tou
• OBSERVATION OF SMALL HEAT SHOCK PROTEIN CHAPERONE ACTIVITY USING A SINGLE MOLECULE PHOTOBLEACHING APPROACH - Lauren Rice
• Characterising the interactions of sHsps with mature α-synuclein fibrils - Nicola Auld
• Characterisation of Axundead, a novel downstream regulator of Wallerian degeneration  - Helen Y McGuinness
• Engineering ABC toxins to target cancer cells - Chandra M. J. Rodriguez
• INVESTIGATING THE INTERACTIONS OF FRAGMENT ANALOGUES AGAINST A BACTERIAL RECEPTOR AND ITS HUMAN HOMOLOG FOR ANTIBIOTIC LEADS - Madeline S McRae
• Peroxiredoxins as biomarkers of oxidative stress - Te-Rina King-Hudson
• Repurposing the Plasmodium falciparum mitosis mechanism to drive cellular elongation and chromosomes reorganization in gametocytes - Jiahong Li
• InDel puzzles. When Insertions and Deletions tailor coenzyme binding - Saacnicteh Toledo Patino
• Insight into characteristics of drug resistance ABC transporters of pathogenic Candida species.   - Jeeeun JS Shin
• Novel inhibitors of chloride conductance in human excitatory amino acid transporter 1 - Amy Cheng
• Understanding and exploiting RECQL4 interactions for targeted cancer prevention - Courtney Pilcher
• PROTEIN BIOSENSORS FOR DETECTING SMOKE EXPOSURE OF GRAPES - Maria M Fiorito
• Covalent probe reveals Ubc13 interactome in the malaria parasite - Anna Truong
• Structural evidence for the binding of adenovirus protein VII of Psittacine siadenovirus F to the nuclear trafficking protein importin alpha - Ajani Athukorala
• BCL-rambo Phosphorylation States Govern Interactions With The Autophagy-Regulating ATG8 Family Proteins - Shengsheng Zhao
• Investigating the Molecular Details of the Interaction Between Two Important Proteins Vital for Coronavirus Replication - David L Baker
• Screening for deubiquitinases regulating the oncogenic transcription factor ERG - Philipp Schenk
• Structure-function insight into the two-component DNA repair system of Mycobacterium tuberculosis - JOYDEEP BARAL
• Studying the structure and function of the plastid-encoded RNA polymerase (PEP) - Angel Vergara Cruces
• How do pathogenic bacteria adapt to environmental changes during infection? A transcriptional regulator protein, NanR, helps out - David Wood
• Toward a structural understanding of amylin receptor phenotype: implications for therapeutic development for obesity - Jian-Jun Cao
• Characterisation of a Myrtle Rust (Austropuccinia psidii) Effector Protein - Jovarn V Sullivan
• When you are an à la carte eater in a buffet world: Understanding selective bacterial nutrient uptake through structural and functional analysis - Michael C Newton-Vesty
• Substrate processing by p97 ATPase in complex with SAKS1 - Abolfazl Mirzadeh
• Investigating the molecular basis of effector delivery through the bacterial Type IV Secretion System - Doulin C Shepherd
• Deciphering the archaeal origin of eukaryotic Oligosaccharyl transferase machinery - Isaac Carilo
• Helical Intermediate Formation And Its Role in Amyloid of an Amphibian Antimicrobial Peptide - Anup Kumar Prasad
•  The role of the paramyxoviral phosphoprotein as a chaperone of monomeric nucleoprotein - Daniel Body
• Identifying novel inhibitors of transthyretin using structure-based drug design - Bruce A Holdsworth
• Efficient O-demethylation of lignin monoaromatics using the peroxygenase activity of cytochrome P450 enzymes - Alix C Harlington
• The identification and characterisation of RaPID-derived cyclic peptides that target the oxygen-sensing enzyme ADO - Yannasittha Jiramongkol
• Structural basis of frizzled receptor activation upon ligand binding in non-canonical Wnt signalling: - - Susovan Das
• Phosphoribosylaminoimidazole (AIR) carboxylase: reversing evolution to dissect a promising antifungal drug target in Cryptococcus neoformans - Tristan Villamor
• NMR characterization of the RIP homotypic interaction motif in the host adapter protein, RIPK3, and the viral inhibitor of necroptosis, M45 - Nikhil R Varghese
• Investigating the interplay between chromatin modifications and regulators of gene expression - Clement Luong
• Analysis of PINK1 nucleotide binding by cryo-EM - Zhong Yan Gan
• Designer Solvents for Protein Stability and Solubility - Stuart J Brown
• Systematic evaluation of computational tools to predict the effects of mutations on protein stability in the absence of experimental structures - Qisheng Pan
• Developing phage depolymerase enzymes to disarm Klebsiella pneumoniae - Daniel E Williams
• MDSPACE: Extracting continuous conformational landscapes from cryo-EM singleparticle datasets using 3D-to-2D flexible fitting based on Molecular Dynamicssimulation - Rémi Vuillemot
• Surveying triosephosphate isomerase diversity in photosynthetic organisms - Gareth Jones
• Prediction of oncogenic mutations in VHL disease   - Adam Serghini

• Proteins through the ages - my long and winding road - Juliet Gerrard

• An atypical Ubiquitin E3 ligase architecture in the N-degron pathway - Peter D Mabbitt
• Molecular Insights Into The Enzyme- Catalysed Syntheses Of Narrow-Spectrum Macrolide Antibiotics   - Shadi Maghool
• Disordered regions of DBHS proteins have distinct roles in protein condensation behaviour - Andrew C Marshall
• Real-time single-molecule observation of chaperone-assisted protein folding - Nicholas Marzano
• DNAJB chaperones suppress destabilised protein aggregation via a region distinct from that used to inhibit amyloidogenesis - Shannon McMahon
• Structure of the BAK-inhibiting antibody 14G6 bound to BAK identifies core-latch separation and α1-dissociation as essential events in BAK activation - Michelle S Miller
• Membrane mimetic systems and their effect on structure resolution, conformation and dynamics of GPCRs - Nazanin Mohebali
• Characterisation of the solute-binding protein ModA from Pseudomonas aeruginosa and its role in molybdenum homeostasis - Dalton H. Y. Ngu
• Characterisation of the solute-binding protein ModA from Pseudomonas aeruginosa and its role in molybdenum homeostasis - Dalton H. Y. Ngu
• Integrative structural approaches reveal dynamic interactions of NS2B-NS3 protease from DENV4  - Wint Wint Phoo
• The structure of the complex between the arsenite oxidase from Pseudorhizobium banfieldiae sp. str. NT-26 and its native electron acceptor cytochrome c₅₅₂. - Nilakhi Poddar
• The baby steps of an artificial protein walker - Neil O Robertson
• Exploring the Protein-Protein Interaction Landscape using Artificial Intelligence - Carlos H. M. Rodrigues
• Investigating the molecular evolution of carbapenem-resistance in Klebsiella quasipneumoniae - Natalia C. Rosas
• Refinement of AlphaFold models of RNA editing factors using Small Angle X-ray Scattering - Santana Royan
• Characterising a drug and metabolite binding site that modulates the activity of the Fanconi Anaemia ubiquitin E3 ligase complex - Michael F Sharp
• Discovery of a conserved rule and role behind the assembly of β-barrel membrane proteins - Takuya Dr Shiota
• Characterisation of an aerolysin-like insecticidal pore-forming protein from Coprinopsis cinerea - Bradley A Spicer
• The identification and characterisation of an unusual disulfide bond forming protein from Salmonella Typhimurium - Pramod Subedi
• A Structurally Characterized Staphylococcus aureus Evolutionary Escape Route from Treatment with the Antibiotic Linezolid - Kher Shing Tan
• High-throughput techniques enable structure guided drug discovery against an inflammatory target: NLRP3 - Andrew P Thompson
• Functional interaction between compound heterozygous TERT mutations causes severe Telomere Biology Disorder - Jia Q Truong
• Structure-informed annotation of phage protein function with deep learning - Jiawei Wang
• Structures of Periscope Protein lectin-like adhesins Aap, SasG and Pls infer a non-canonical interaction with the host cell - Fiona Whelan
• Directed evolution of Rubisco to improve plant productivity - Spencer Whitney
• Structural and functional characterisation of AAA+ ATPase p97 protein homologs from malaria parasite - Mehdi Youssefi Matak
• Rapid Elaboration of Fragments into Leads (REFiL) - Luke A Adams
• Biological complexes with molecular weights of <100 kDa can be resolved to high resolution using single-particle Cryo-EM - Ryan Shaw