Monday, 6th February The 48th Lorne Conference on Protein Structure and Function 2023

• Structure Determination of Macromolecules by MicroED - Hongyi Xu
• Structure of the Human T cell Leukaemia Virus capsid protein – a new drug target - Ruijie Yu
• Reshaping the Energy Landscapes of de novo Designed Fluorescent Proteins - Colin A Smith
• Developing C-reactive protein modulators as new treatments for inflammation   - Karen S Cheung Tung Shing
• Structure, function and engineering of wild-type and artifical tandem repeat proteins - Barry Stoddard

Protein Society Speaker - Jean Baum

• Illuminating the Biochemical Activity Architecture of the Cell - Jin Zhang
• UNRAVELLING THE MOLECULAR ARCHITECTURE OF THE COMMANDER ASSEMBLY - Michael D Healy
• Molecular basis of auto-inhibition, activation and substrate recognition of SARM1, the executioner of axon degeneration - Weixi Gu
• Optogenetics and Synthetic Protein Condensates for Controlling and Visualizing Cell Signaling in Living Cells and Animals - Won Do Heo

• Fungtion: predicting and visualizing fungal effectors with deep learning - Jiahui Li
• Structural studies of recently identified Bacteroides fragilis Cholesterol-dependent Cytolysin Like (CDCL) proteins - Riya Joseph
• Obtaining sulfide for iron-sulfur cluster biogenesis in Mycobacterium tuberculosis - Stephanie M. Stuteley
• Deciphering the molecular mechanism of HOIL-1, an unconventional ubiquitin ligase - Xiangyi Susie Wang
• The structural basis of hydrogen oxidation in Mycobacterium smegmatis - Ashleigh Kropp
• DDMut: predicting mutation effects on protein stability using deep learning - Yunzhuo Zhou
• A Novel Type VI Secretion System DNase Effector and Immunity Protein Pair from Acinetobacter baumannii - Brooke K Hayes
• A Structural Investigation into the Allosteric Regulation of the Cholecystokinin Type 1 Receptor - Jack Tovey
• The Cryo-EM Structure of Human OCT1 in Monomeric and Pseudo-Dimeric Forms - Yi C Zeng
• A clinically-relevant mutation of glucagon-like peptide 1 receptor alters extracellular loop dynamics - Kieran Deane-Alder
• Categorization of substrate OMPs by dependence on accessory proteins of the BAM complex - Nakajohn Mr. Thewasano
• Engineering of Enzymatic Activity of DNA/RNA Methyltransferase M.EcoGII by Ancestral Sequence Reconstruction - Yoshiki Ochiai
• A temperate bacteriophage equips its Klebsiella hosts with a potent interbacterial toxin - Sally Byers
• Structural studies of cell signalling adaptor protein STimulator of INterferon Genes in complex with small molecule inhibitors - Maria Eleni Georgopoulou
• A novel interaction between the MRN and the SOSS1 complex plays an important role in DNA repair - Serene El-Kamand
• Uncovering the molecular basis for ion coupling mechanisms in the SLC1A glutamate transporter family - Chelsea Briot
• kinCSM: using graph-based signatures to predict small molecule CDK2 inhibitors - Yunzhuo Zhou
• Stabilisation Methods for the Parathyroid Receptor 1 and its Constitutively Active Mutants - Isabella C Russell
• Insight into key sporulation proteins from Clostridioides difficile   - Clara E Bate
• A CONVENIENT, RAPID AND SENSITIVE METHOD FOR DETECTING THE QUATERNARY STATE OF SINGLE-CHAIN VARIABLE FRAGMENTS: POSSIBLE APPLICATIONS FOR QUALITY CONTROL OF ANTIBODIES AND DRUG DESIGN - Mohammad Pourhassan Moghaddam
• Structural Investigations of Bacteriophage Derived Polysaccharide Depolymerase Enzymes - Arrafy Rahman
• Investigating peptide-induced conformational dynamics of amylin receptors using HDX-MS - Cameron J Fairweather
• Application of cryo-EM to understand the molecular structure and signal transduction of the Ephrin Receptor Pseudokinase EphA10 - Hai-Tian Chen
• INVESTIGATING THE MYCOBACTERIUM TUBERCULOSIS OUTER ENVELOPE AND MYCOMEMBRANE-ASSOCIATED NUTRIENT TRANSPORTERS - Fabian FM Munder
• Computing Spatial Mutation Intolerance to Assess Selective Pressure Across the Human Proteome - Aaron Kovacs
• Modelling bioactivity of GPCR ligands using machine learning - Joao P. L. Velloso
• Elucidating the structural architecture of S-type pentatricopeptide repeat proteins and their RNA editing domains - Anuradha Mrs Pullakhandam
• Agonist-mediated GPR52 trafficking and their binding pocket revealed by cryo-EM - Yao Lu
• Investigating the RBR E3 ligase RNF14 and K6 ubiquitin chains in gene regulation  - Sarah Trevelyan
• Rational protein engineering of thermostable and active PET hydrolases - Yvonne Joho
• Structural and Functional analysis of the TIR-domain in Toll-like receptors 7, 8, and 9 signaling and the Interactions with adaptor proteins - XIAOQI QIAN
• Investigating the redox chemistry of mitochondrial proteins and co-factors - India R. Wright
• Towards a structural understanding of GPR151 structure and pharmacology - Dongju DL Lee
• Structural and mechanistic understanding of GIPR and GLP-1R co-agonism - Qinghao Ou
• Characterisation of the pathogenic effect of missense mutations in proteins via machine learning - Qisheng Pan
• Improving GPCRs stability and expression using point mutations - Joao P. L. Velloso
• Using cryo-EM to solve the P2X1 receptor structure – a target for male contraception - Felix M Bennetts
• Elucidation of Lanthionine Installation by Class V Lanthipeptide Synthetases - George Randall
• Deciphering the relationship between protein sequence and stability - Vladimir Morozov
• Predicting toxicity of a protein from its primary sequence - Vladimir Morozov
• Structure of the pituitary adenylate cyclase-activating polypeptide 1 receptor bound to its secondary signal transducer Gq - Theodore Nettleton
• Structure of the Human T cell Leukaemia Virus capsid protein – a new drug target - Ruijie Yu
• Structural Characterisation the Bacterial Phage Secretion System - Evie Mansfield
• Investigating the structure and function of PAC1R splice isoforms - Jessica Lu
• A comparative study of the Nsp9 RNA binding interface between SARS CoV-2 and MERS - Gayathri Mani
• CSM-peptides: a computational approach to rapid identification of therapeutic peptides - Xiaotong Gu
• STRUCTURAL AND FUNCTIONAL CHARACTERIZATION OF dsDNA BINDING BY THE MyD88 ADAPTOR PROTEIN - Zannati Ferdous Zaoti
• The effect of a zwitterionic interface on the self-assembly, dynamics and activity of an antimicrobial peptide, Uperin 3.5 - Sucharita Banerjee
• FUNCTIONAL CHARACTERISATION OF PLANT TIR DOMAINS AND THEIR ROLE IN PLANT INNATE IMMUNITY - Bryan Y.J. Lim
• Biochemical Characterisation of the MEKK1 SWIM Domain - Alex Bohles
• The Fluoro renaissance  A rebirth of techniques and applications for the genetic incorporation of fluorinated non-canonical amino acids - Edan I Habel
• UNDERSTANDING THE MOLECULAR MACHINERY OF THE L PROTEIN FROM EBOLA VIRUS - Raphael Caballes
• Deep Mutational Scanning of SARS-CoV-2 Proteases - Xinyu Wu
• Deciphering the Structures of DRP1 and OPA1: Major players in Mitochondrial Fission and Fusion - Javaid Jabbar
• Investigating mechanisms of molecular chaperone function at the single-molecule level - Bailey Skewes

• T-cell and B-cell antigen receptors share a conserved core transmembrane structure - Samyuktha Ramesh
• Structural basis of the supercoiled filamentous protease, meprin α, in complex with a small molecule inhibitor by cryoEM. - Charles Bayly-Jones
• Secreted dengue virus NS1 is predominantly dimeric and in complex with high-density lipoprotein - Wint Wint Phoo
• Speaking with the dead: how human RIPK3 activates MLKL during necroptosis - Yanxiang Meng

Session Sponsored by

• Characterizing Amyloid-Forming IgG Light and Variable Chains Using Microfluidic Modulation Spectroscopy - Valerie I Collins
• Investigating the contribution of cysteine protease legumain to oral cancer progression - Bethany M Anderson
• WIGGLE: Software for interactive structural dynamics analysis - Charles Bayly-Jones
• Exploration of diverse agonism of the Calitonin receptor by using high-resolution single particle cryo electron microscopy. - Matthew Belousoff
• Glutenin and bovine satellite cells - investigating food matrix interactions and their impact on sensory - Rachel Z Bennie
• CryoEM structure and inhibition mechanism of the Wnt-modifying enzyme, Porcupine. - Katrina Black
•   USING CRISPR ENGINEERING AND CRYO-EM FOR STRUCTURE GUIDED DESIGN OF NEXT GENERATION LIGHT DRIVEN MICROALGAE-BASED INDUSTRIES - Farrah W A Blades
• Discovery of novel allosteric binding sites for selective allosteric modulators at the M₅ muscarinic acetylcholine receptor - Wessel A C Burger
• Elucidating the role of the VPS13-family of lipid transporters in neurodegenerative disease - Sylvie Callegari
• The MX3 beamline at the Australian Synchrotron - Eleanor C Campbell
• Structural and Functional Diversity among Agonist-Bound States of the GLP-1 Receptor - Brian P Cary
• Chlorosulfolipid (Danicalipin A) Membrane Structure: Hybrid Molecular Dynamics Simulation Studies - Rakwoo Chang
• Structure of a dimeric tripartite ATP-independent periplasmic (TRAP) transporter from Haemophilus influenzae. - Michael Currie
• Two-step receptor binding required for bacteriophage infection of Klebsiella pneumoniae. - Rhys A Dunstan
• A complex machine for lipid transport across the cell envelope of Mycobacterium tuberculosis - Damian C Ekiert
• Structure of the bacterial flagellar MS-ring: An adaptor between secretion and rotation - Emily J Furlong
•  Ribosome-associated factors mediating protein biosynthesis in response to stress - Yong-Gui Gao
• Oxidation induces amyloid formation of the tumour suppressor protein p16^ink4a - Christoph Goebl
• Specific ion-binding sites of ionic liquids with proteins - Tamar L Greaves
• Use of SPR to characterize biomolecular interactions. - Menachem J Gunzburg
• Understanding the structure and function of doublecortin-like kinases - Joshua M Hardy
• Perforin pore formation and lipid specificity - Adrian W Hodel
• Illuminating the ‘dark’ kinases, PSKH1 and PSKH2, and their role in inflammatory disease - Chris Horne
• Structural studies of the membrane-bound protein Ezrin using cryo-electron microscopy - Hasti Iranmanesh
• SDS capillary gel electrophoresis of protein samples on a multi-capillary system - Peter E Jackson
• Adapting fungal strategies to deliver antifungal agents - Caitlin L Johnston
• CryoEM studies of viral IGF-like ligands of the human IGF receptor - Nicholas S Kirk
• Complete structures of the YenTc holotoxin pre-pore and pore reveal the structural and evolutionary basis for chitinase incorporation into ABC toxins - Michael J Landsberg
• Biomineralization of short-chain organosulfonates: charting metabolic pathways by structural enzymology - Mihwa Lee
• Molecular characterisation of the Tumbleweed motor protein on DNA tracks - Chu Wai Liew
• Investigation of hydrophobin conjugation to Leaf Compost Cutinase (LCC) to enhance polyethylene terepththalate (PET) degradation - Shaun Lott