Wallerian degeneration is a conserved program of injury-induced axon degeneration and is analogous to the blockage of transport that characterises the early stages of many neurodegenerative diseases. In recent years, the TLR adaptor SARM1 has been well characterised as the initiator of Wallerian degeneration. SARM1 has intrinsic NADase activity through the dimerization of TIR domains, and this NADase activity is essential for Wallerian degeneration. However, details of the Wallerian degeneration pathway downstream of SARM1 are not well understood. Axundead (Axed) is a regulator of Wallerian degeneration in Drosophila, with loss of function mutants providing near-total protection from SARM1-dependent axon degeneration. Axed is a novel member of a family of BTB-domain containing proteins, which play roles in a range of cellular functions, including cytoskeleton organisation, transcriptional regulation, and protein ubiquitination. Presented here is preliminary research that suggests Axed may play a key role in the dysfunction of energy metabolism leading to the functional death of the axon. As a downstream converging point for axon death pathways, Axed represents an ideal target of therapeutic intervention for axon degeneration in disease.